Greyhound bus that originated in Los Angeles and was carrying 47 people has crashed in the Fresno area, killing at least six people, according to authorities.

The bus, running on Greyhound Route 6888, left Los Angeles for Sacramento around 6 p.m. Wednesday and made a stop in Fresno.

While traveling on Highway 99, the bus driver swerved to avoid another crash involving an overturned minivan and slammed into the concrete center divider before hitting a Chevy Blazer and a tree around 2:14 a.m. Thursday, CHP Officer Michelle Sigmond said.

Six people were killed in the crash, including at least five victims inside the bus, Sigmond said. It's believed the male bus driver was among the deceased.

Police told KTLA at least 10 others were hurt, ranging from serious to minor injuries.

The cause of the crash is under investigation.